TDT, Human (His)

TDT protein, a template-independent DNA polymerase, non-specifically adds deoxynucleoside 5'-triphosphates to the 3'-end of a DNA initiator. It crucially contributes to in vivo processes, particularly adding nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during B- and T-cell maturation. TDT Protein, Human (His) is the recombinant human-derived TDT protein, expressed by E. coli , with N-6*His labeled tag. The total length of TDT Protein, Human (His) is 509 a.a., with molecular weight of ~62.0 kDa.

MDPPRASHLS PRKKRPRQTG ALMASSPQDI KFQDLVVFIL EKKMGTTRRA FLMELARRKG FRVENELSDS VTHIVAENNS GSDVLEWLQA QKVQVSSQPE LLDVSWLIEC IRAGKPVEMT GKHQLVVRRD YSDSTNPGPP KTPPIAVQKI SQYACQRRTT LNNCNQIFTD AFDILAENCE FRENEDSCVT FMRAASVLKS LPFTIISMKD TEGIPCLGSK VKGIIEEIIE DGESSEVKAV LNDERYQSFK LFTSVFGVGL KTSEKWFRMG FRTLSKVRSD KSLKFTRMQK AGFLYYEDLV SCVTRAEAEA VSVLVKEAVW AFLPDAFVTM TGGFRRGKKM GHDVDFLITS PGSTEDEEQL LQKVMNLWEK KGLLLYYDLV ESTFEKLRLP SRKVDALDHF QKCFLIFKLP RQRVDSDQSS WQEGKTWKAI RVDLVLCPYE RRAFALLGWT GSRQFERDLR RYATHERKMI LDNHALYDKT KRIFLKAESE EEIFAHLGLD YIEPWERNA