GPR183 antagonist-2
GPR183 antagonist-2 (compound 32) is a selective GPR183 antagonist with good water solubility and excellent pharmacokinetic properties. GPR183 antagonist-2 significantly reduces paw and joint swelling and gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a collagen-induced arthritis (CIA) mouse model in a dose-dependent manner. GPR183 antagonist-2 can be used in the study of autoimmune diseases[1].
Product Specifications
CAS Number
2924063-98-7
UNSPSC
12352005
Target
EBI2/GPR183
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gpr183-antagonist-2.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
FC(O1)(F)OC2=C1C=CC(/C=C/C(N3CCN(C(C4=CN=C(OC)N=C4)=O)CC3)=O)=C2
Molecular Formula
C20H18F2N4O5
Molecular Weight
432.38
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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