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GPR183 antagonist-2

GPR183 antagonist-2 (compound 32) is a selective GPR183 antagonist with good water solubility and excellent pharmacokinetic properties. GPR183 antagonist-2 significantly reduces paw and joint swelling and gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a collagen-induced arthritis (CIA) mouse model in a dose-dependent manner. GPR183 antagonist-2 can be used in the study of autoimmune diseases[1].

Product Specifications

CAS Number

2924063-98-7

UNSPSC

12352005

Target

EBI2/GPR183

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gpr183-antagonist-2.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

FC(O1)(F)OC2=C1C=CC(/C=C/C(N3CCN(C(C4=CN=C(OC)N=C4)=O)CC3)=O)=C2

Molecular Formula

C20H18F2N4O5

Molecular Weight

432.38

References & Citations

[1]Xi J, et al. Discovery of a First-in-Class GPR183 Antagonist for the Potential Treatment of Rheumatoid Arthritis. J Med Chem. 2023 Dec 14;66 (23) :15926-15943.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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