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IMM-H004

IMM-H004, a coumarin derivative, possesses neuroprotective and potent free radical scavenging abilities. IMM-H004 significantly inhibits amyloid-β (Aβ) -induced cytotoxicity and apoptosis, offering potential value for research into neurodegenerative diseases such as Alzheimer's disease. Additionally, IMM-H004 is also capable of effectively blocking the calcium mobilization and chemotaxis induced by CKLF1-C27 , thereby alleviating asthmatic pathological changes in the lung tissue of CKLF1 transgenic mice[1].

Product Specifications

CAS Number

1456807-80-9

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/imm-h004.html

Smiles

O=C1OC2=C(C(C)=C1N3CCN(CC3)C)C(OC)=CC(O)=C2

Molecular Formula

C16H20N2O4

Molecular Weight

304.34

References & Citations

[1]Song X Y, et al. IMM-H004, a novel coumarin derivative compound, protects against amyloid beta-induced neurotoxicity through a mitochondrial-dependent pathway[J]. Neuroscience, 2013, 242: 28-38.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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