Sarafotoxin S6b
Product Specifications
UNSPSC Description
Sarafotoxin S6b is a vasoconstrictor peptide, and a non-selective endothelin receptor agonist. Sarafotoxin S6b can induce contraction in isolated human coronary arteries , the Ki values of Coronary artery, Saphenous vein and Coronary artery are 0.27, 0.55 and 19.5 nM, respectively[1].
Target Antigen
Endothelin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sarafotoxin-s6b.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@]2([H])NC([C@@H](NC([C@@H](NC([C@@H](NC([C@](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@](CSSC2)([H])NC([C@@H](NC([C@H](CSSC1)N)=O)CO)=O)=O)CCCCN)=O)CC(O)=O)=O)CCSC)=O)([H])[C@H](O)C)=O)CC(O)=O)=O)CCCCN)=O)CCC(O)=O)=O)=O)CC(C)C)=O)CC3=CC=C(C=C3)O)=O)CC4=CC=CC=C4)=O)N[C@@H](CC5=CN=CN5)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC6=CNC7=CC=CC=C67)=O)=O)=O)=O)=O
Molecular Weight
2563.92
References & Citations
[1]P S Devadason et al. Comparison of the contractile effects and binding kinetics of endothelin-1 and sarafotoxin S6b in rat isolated renal artery. Br J Pharmacol. 1997 May;121(2):253-63.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P3433/Sarafotoxin-S6b-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P3433/
Clinical Information
No Development Reported
CAS Number
120972-53-4
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