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Mature TGF beta 1/TGFB1, Human (Biotinylated, HEK293, Avi)

Selected Variant

HY-P78213-01

Size: 20 µg

TGF beta 1/TGFB1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. TGF beta 1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, apoptosis, and can regulate the expression and activation of other growth factors, including interferon gamma and tumor necrosis factor alpha. Mature TGF beta 1/TGFB1 Protein, Human (Biotinylated, HEK293, Avi) is the recombinant human-derived Mature TGF beta 1/TGFB1 protein, expressed by HEK293 , with C-Avi labeled tag.

Product Specifications

Product Name Alternative

Mature TGF beta 1/TGFB1 Protein, Human (Biotinylated, HEK293, Avi), Human, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/mature-tgf-beta-1-tgfb1-protein-human-biotinylated-hek293-avi.html

Purity

95.00

Molecular Formula

7040 (Gene_ID) P01137 (A279-S390) (Accession)

Molecular Weight

Approximately 15-18 kDa under reduced (R) conditions, 26-30 kDa under non reducing (N) conditions, based on SDS-PAGE, due to the glycosylation.

References & Citations

[1]Ghadami M, et al. Genetic mapping of the Camurati-Engelmann disease locus to chromosome 19q13.1-q13.3. Am J Hum Genet. 2000 Jan;66 (1) :143-7.|[2]Vaughn SP, et al. Confirmation of the mapping of the Camurati-Englemann locus to 19q13. 2 and refinement to a 3.2-cM region. Genomics. 2000 May 15;66 (1) :119-21.|[3]Chen Q, et al. Sustained induction of collagen synthesis by TGF-β requires regulated intramembrane proteolysis of CREB3L1. PLoS One. 2014 Oct 13;9 (10) :e108528.|[4]Kotlarz D, et al. Human TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathy. Nat Genet. 2018 Mar;50 (3) :344-348.|[5]Hwangbo C, et al. Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization. Oncogene. 2016 Jan 21;35 (3) :389-401.|[6]Letterio JJ, rt al. Regulation of immune responses by TGF-beta. Annu Rev Immunol. 1998;16:137-61.

Shipping Conditions

Room temperature in continental US; may vary elsewhere.

Storage Conditions

Stored at -20°C for 2 years

Scientific Category

Recombinant Proteins

Available Sizes

Price

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