(R) -5-Oxopyrrolidine-2-carboxylic acid

(R) -5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of D-glutamate. (R) -5-Oxopyrrolidine-2-carboxylic acid can be used in the research of metabolic syndrome and end-stage renal disease[1][2][3].

Product Specifications

CAS Number

[4042-36-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Derivative

Type

Natural Products

Related Pathways

Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/r-5-oxopyrrolidine-2-carboxylic-acid.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)[C@@H](CC1)NC1=O

Molecular Formula

C5H7NO3

Molecular Weight

129.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Ariyoshi M, et al. D-Glutamate is metabolized in the heart mitochondria. Sci Rep. 2017 Mar 7;7:43911. |[2]Shim K, et al. Exploratory metabolomics of nascent metabolic syndrome. J Diabetes Complications. 2019 Mar;33 (3) :212-216.|[3]Palekar AG, et al. Accumulation of 50oxo-L-proline and 5-oxo-D-proline in the blood plasma in end stage renal disease. Biochem Med. 1975 Nov;14 (3) :339-45.