PROTAC MLKL Degrader-1
PROTAC MLKL Degrader-1 (Compound 36) is a PROTAC degrader of MLKL, with a Dmax > 90%. PROTAC MLKL Degrader-1 contains modified CRBN ligands, linker and Lenalidomide -linker fragments. PROTAC MLKL Degrader-1 abrogates cell death in a TSZ model of necroptosis.
Product Specifications
CAS Number
3032600-90-8
UNSPSC
12352005
Target
Mixed Lineage Kinase; PROTACs
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/protac-mlkl-degrader-1.html
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(NN=C1C2=CC=C(C=C2)NS(C(F)F)(=O)=O)NC3=CC=CC(OCCCCCCCC(N4CCC5(CCN(CC5)C(C6=CC=C(C(N7CCC(NC7=O)=O)=C6)OC)=O)CC4)=O)=C3)N
Molecular Formula
C46H55F2N9O9S
Molecular Weight
948.05
References & Citations
[1]Rathje OH, Perryman L, Payne RJ, Hamprecht DW. PROTACs Targeting MLKL Protect Cells from Necroptosis. J Med Chem. 2023 Aug 3.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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