Adipokinetic hormone I (Locusta migratoria)

Adipokinetic hormone I (Locusta migratoria) (Lom-AKH-I) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor (s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs) [1][3].

Product Specifications

CAS Number

[61627-67-6]

Product Name Alternative

Lom-AKH-I

UNSPSC

12352209

Target

Endogenous Metabolite

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/adipokinetic-hormone-i-locusta-migratoria.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1N(CCC1)C([C@H]([C@H](O)C)NC([C@@H](NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@@H]2CCC(N2)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)N[C@@H](CC(N)=O)C(N[C@H](C(NCC(N[C@H](C(N)=O)[C@H](O)C)=O)=O)CC4=CNC5=CC=CC=C45)=O

Molecular Formula

C54H74N14O15

Molecular Weight

1159.25

References & Citations

[1]Oudejans RC, et al. Locust adipokinetic hormones: carrier-independent transport and differential inactivation at physiological concentrations during rest and flight. Proc Natl Acad Sci U S A. 1996 Aug 6;93 (16) :8654-9. |[2]Gautam UK, et al. Adipokinetic hormone promotes infection with entomopathogenic fungus Isaria fumosorosea in the cockroach Periplaneta americana. Comp Biochem Physiol C Toxicol Pharmacol. 2020 Mar;229:108677. |[3]Vroemen SF, et al. Stimulation of glycogenolysis by three locust adipokinetic hormones involves Gs and cAMP. Mol Cell Endocrinol. 1995 Feb;107 (2) :165-71. |[4]Goldsworthy, et al. The relative potencies of two known locust adipokinetic hormones. 1986;32 (1) :95-101.