Proadrenomedullin (1-20), human

Proadrenomedullin (1-20), human is a potent hypotensive and catecholamine release–inhibitory peptide released from chromaffin cells. Proadrenomedullin (1-20) inhibits catecholamine secretion in PC12 pheochromocytoma cells (IC50 ≈ 350 nM) by suppressing Na+/Ca2+ influx and blocking desensitization. Proadrenomedullin (1-20), human specifically acts on nicotinic cholinergic receptors in a non competitive manner. Proadrenomedullin (1-20), human can be used for research on conditions such as hypertension[1][2].

Product Specifications

CAS Number

[150238-87-2]

Product Name Alternative

ProAM N20, Human; PAMP-20, human

UNSPSC

12352209

Target

Calcium Channel; nAChR; Sodium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/proadrenomedullin-1-20-human.html

Purity

99.71

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N=C(N)NCCC[C@H](NC([C@@H](N)C)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)=O)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C112H178N36O27

Molecular Weight

2460.84

References & Citations

[1]Mahata M, et al. Proadrenomedullin N-terminal 20 peptide: minimal active region to regulate nicotinic receptors. Hypertension. 1998 Nov;32 (5) :907-16.|[2]Belloni AS, et al. Proadrenomedullin N-terminal 20 peptide (PAMP), acting through PAMP (12-20) -sensitive receptors, inhibits Ca2+-dependent, agonist-stimulated secretion of human adrenal glands. Hypertension. 1999 May;33 (5) :1185-9.