Edoxaban (tosylate monohydrate)

Edoxaban (DU-176b) monohydrate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban monohydrate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban monohydrate can be used for preventing thromboembolic disease research[1].

Product Specifications

CAS Number

[1229194-11-9]

Product Name Alternative

DU-176b (monohydrate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Factor Xa; Thrombin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Edoxaban-tosylate-monohydrate.html

Purity

99.97

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic)

Smiles

O=C(N(C)C)[C@@H](CC1)C[C@H]([C@H]1NC(C(NC(C=C2)=NC=C2Cl)=O)=O)NC(C3=NC(CC4)=C(CN4C)S3)=O.O=S(C5=CC=C(C)C=C5)(O)=O.O

Molecular Formula

C31H40ClN7O8S2

Molecular Weight

738.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Furugohri T, et al. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost. 2008 Sep;6 (9) :1542-9.