CCT018159

CCT018159, a 3,4-diaryl pyrazoleresorcinol, is a ATP-competitive HSP90 ATPase activity inhibitor with IC50s of 3.2 and 6.6 µM for human Hsp90β and yeast Hsp90, respectively. CCT018159 caused cell cytostasis associated with a G1 arrest and induces apoptosis. CCT018159 inhibits key endothelial and tumor cell functions implicated in invasion and angiogenesis[1].

Product Specifications

CAS Number

[171009-07-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Apoptosis; HSP

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cct018159.html

Purity

99.19

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=C(C2=CC3=C(OCCO3)C=C2)C(C4=CC(CC)=C(O)C=C4O)=NN1

Molecular Formula

C20H20N2O4

Molecular Weight

352.38

Precautions

H302, H315, H319

References & Citations

[1]Swee Y Sharp, et al. In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. Cancer Res. 2007 Mar 1;67 (5) :2206-16.