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Tribuloside

Tribuloside is a flavonoid and PDE4 inhibitor (IC50: 6 μM) . Tribuloside exhibits antibacterial and antioxidant activities, capable of scavenging DPPH free radicals. Tribuloside also promotes melanogenesis. Tribuloside can be used in the research of hypopigmentary diseases, sun protection, and inflammatory diseases such as acute lung injury[1][2][3].

Product Specifications

CAS Number

22153-44-2

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Interleukin Related; Microphthalmia Associated Transcription Factor (MITF) ; Phosphodiesterase (PDE) ; PKA; TRP Channel; Tyrosinase

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tribuloside.html

Purity

99.26

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)COC(/C=C/C3=CC=C(O)C=C3)=O)=C(C4=CC=C(O)C=C4)OC5=CC(O)=CC(O)=C51

Molecular Formula

C30H26O13

Molecular Weight

594.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Christopher R, et al. A new cinnamoylglycoflavonoid, antimycobacterial and antioxidant constituents from Heritiera littoralis leaf extracts. Nat Prod Res. 2014;28 (6) :351-8.|[2]Cao Y, et al. Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport. J Ethnopharmacol. 2024 Apr 6;323:117673.|[3]Yang Z, et al. Tribuloside: Mechanisms and Efficacy in Treating Acute Lung Injury Revealed by Network Pharmacology and Experimental Validation. Dose Response. 2024 May 8;22 (2) :15593258241251594.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

IL-1; IL-6; PDE4

Available Sizes

Frequently Asked Questions

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