Saccharic acid
Saccharic acid is a competitive inhibitor of β-glucuronidase. Saccharic acid considerably retards hydrolysis of the glucuronide of 'l-ortho-hydroxyphenylazo-2-naph-thol' by frozen mouse kidney sections, but has no effect on liver regeneration following damage and on growth in infant mice[1][2].
Product Specifications
CAS Number
87-73-0
UNSPSC
12352211
Hazard Statement
H314
Target
β-glucuronidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/saccharic-acid.html
Purity
98.0
Solubility
H2O : 250 mg/mL (ultrasonic)
Smiles
[C@H]([C@@H]([C@H](C(=O)O)O)O)([C@@H](C(=O)O)O)O
Molecular Formula
C6H10O8
Molecular Weight
210.14
Precautions
H314
References & Citations
[1]Challenger F, et al. Formation of organic acids from sugars by Aspergillus niger[J]. Nature, 1927, 119 (3001) : 674-674.|[2]KARUNAIRATNAM MC, et al. The inhibition of beta-glucuronidase by saccharic acid and the role of the enzyme in glucuronide synthesis. Biochem J. 1949;44 (5) :699-604.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
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