Saccharic acid

Saccharic acid is a competitive inhibitor of β-glucuronidase. Saccharic acid considerably retards hydrolysis of the glucuronide of 'l-ortho-hydroxyphenylazo-2-naph-thol' by frozen mouse kidney sections, but has no effect on liver regeneration following damage and on growth in infant mice[1][2].

Product Specifications

CAS Number

[87-73-0]

UNSPSC

12352211

Hazard Statement

H314

Target

β-glucuronidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/saccharic-acid.html

Purity

98.0

Solubility

H2O : 250 mg/mL (ultrasonic)

Smiles

[C@H]([C@@H]([C@H](C(=O)O)O)O)([C@@H](C(=O)O)O)O

Molecular Formula

C6H10O8

Molecular Weight

210.14

Precautions

H314

References & Citations

[1]Challenger F, et al. Formation of organic acids from sugars by Aspergillus niger[J]. Nature, 1927, 119 (3001) : 674-674.|[2]KARUNAIRATNAM MC, et al. The inhibition of beta-glucuronidase by saccharic acid and the role of the enzyme in glucuronide synthesis. Biochem J. 1949;44 (5) :699-604.