TPE-MI
TPE-MI (Tetraphenylethene maleimide) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm) . TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasitesPlasmodium falciparum [1][2].
Product Specifications
CAS Number
1245606-71-6
Product Name Alternative
Tetraphenylethene maleimide
UNSPSC
12171500
Hazard Statement
H302, H315, H319
Target
Huntingtin; Parasite
Type
Dye Reagents
Related Pathways
Anti-infection; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tpe-mi.html
Purity
98.93
Solubility
DMSO : 8.57 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C=C1)N(C2=CC=C(/C(C3=CC=CC=C3)=C(C4=CC=C(C)C=C4)/C5=CC=CC=C5)C=C2)C1=O
Molecular Formula
C31H23NO2
Molecular Weight
441.52
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Isoform
Plasmodium
Available Sizes
Frequently Asked Questions
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