Synaptamide

Synaptamide (Dehydroepiandrosteron; DHEA) is an endogenous metabolite and structural analogue of Anandamide. Synaptamide binds to both the cannabinoid-1 and 2 (CB1 and CB2) cannabinoid receptors and has anti-inflammatory properties. Synaptamide is the first small-molecule endogenous ligand of an adhesion G protein-coupled receptor (aGPCR) [1] [2][3].

Product Specifications

CAS Number

[162758-94-3]

Product Name Alternative

N-Docosahexaenoyl ethanolamine (DHEA) ; Docosahexaenoyl ethanolamide

UNSPSC

12352211

Hazard Statement

H225, H319

Target

Cannabinoid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Synaptamide.html

Concentration

67 mM * 400 μL in Ethanol

Purity

99.30

Solubility

Ethanol : 25 mg/mL (ultrasonic)

Smiles

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(NCCO)=O

Molecular Formula

C24H37NO2

Molecular Weight

371.56

Precautions

H225, H319

References & Citations

[1]Kim HY, et al. Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. Prostaglandins Leukot Essent Fatty Acids. 2013 Jan;88 (1) :121-5.|[2]Rashid MA, et al. N-Docosahexaenoylethanolamine is a potent neurogenic factor for neural stem cell differentiation. J Neurochem. 2013 Jun;125 (6) :869-84.