2,4′-Dihydroxybenzophenone
2,4′-Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of MD2 and blocks the dimerization of TLR4. 2,4′-Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88, p-IRAK4, and NF-κB. 2,4′-Dihydroxybenzophenone is also a UV absorber[1][2].
Product Specifications
CAS Number
131-56-6
Product Name Alternative
Ultraviolet absorber UV-0
UNSPSC
12352005
Hazard Statement
H319, H361, H411
Target
IRAK; MyD88; NF-κB; Reactive Oxygen Species (ROS) ; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/2-4-dihydroxybenzophenone.html
Purity
98.00
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
OC1=CC(O)=C(C(C2=CC=CC=C2)=O)C=C1
Molecular Formula
C13H10O3
Molecular Weight
214.22
Precautions
H319, H361, H411
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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