2,4′-Dihydroxybenzophenone

2,4′-Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of MD2 and blocks the dimerization of TLR4. 2,4′-Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88, p-IRAK4, and NF-κB. 2,4′-Dihydroxybenzophenone is also a UV absorber[1][2].

Product Specifications

CAS Number

[131-56-6]

Product Name Alternative

Ultraviolet absorber UV-0

UNSPSC

12352005

Hazard Statement

H319, H361, H411

Target

IRAK; MyD88; NF-κB; Reactive Oxygen Species (ROS) ; Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/2-4-dihydroxybenzophenone.html

Purity

98.00

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

OC1=CC(O)=C(C(C2=CC=CC=C2)=O)C=C1

Molecular Formula

C13H10O3

Molecular Weight

214.22

Precautions

H319, H361, H411

References & Citations

[1]Kavinda MHD, et al. 2,4'-Dihydroxybenzophenone: A Promising Anti-Inflammatory Agent Targeting Toll-like Receptor 4/Myeloid Differentiation Factor 2-Mediated Mitochondrial Reactive Oxygen Species Production during Lipopolysaccharide-Induced Systemic Inflammation. ACS Pharmacol Transl Sci. 2024 Apr 27;7 (5) :1320-1334. |[2]Fang Z, et al. Effect of Substituent Groups on the Strength of Intramolecular Hydrogen Bonds in 2,4-Dihydroxybenzophenone UV Absorbers. Molecules. 2023 Jun 27;28 (13) :5017.