Pirmenol (hydrochloride)

Pirmenol ((±) -Pirmenol) hydrochloride is an orally active antiarrhythmic agent. Pirmenol hydrochloride inhibits IK.ACh (IC50: 0.1 μM) by blocking mAchR. Pirmenol hydrochloride can be used in the research of cardiovascular disease, such as atrial fibrillation[1][2][4].

Product Specifications

CAS Number

[61477-94-9]

Product Name Alternative

(±) -Pirmenol (hydrochloride) ; CI-845

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAChR; Potassium Channel

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Pirmenol-hydrochloride.html

Concentration

10mM

Purity

99.34

Solubility

DMSO : 66.67 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC(C1=CC=CC=C1)(CCCN2[C@@H](C)CCC[C@H]2C)C3=CC=CC=N3.Cl

Molecular Formula

C22H31ClN2O

Molecular Weight

374.95

Precautions

H302, H315, H319, H335

References & Citations

[1]Watanabe Y, et al. Pirmenol inhibits muscarinic acetylcholine receptor-operated K+ current in the guinea pig heart. Eur J Pharmacol. 1997 Oct 29;338 (1) :71-4.|[2]Schardein JL, et al. Preclinical toxicology studies with a new antiarrhythmic agent: Pirmenol hydrochloride (CI-845) . Toxicol Appl Pharmacol. 1980 Nov;56 (2) :294-301.|[3]T Sawanobori, et al. Electrophysiologic and antiarrhythmic actions of pirmenol on rabbit and guinea pig cardiac preparations. J Cardiovasc Pharmacol. 1990 Dec;16 (6) :975-83. |[4]T E Mertz, et al. Pirmenol hydrochloride (CI-845) : antiarrhythmic profile in coronary artery ligated conscious dogs. J Cardiovasc Pharmacol. 1980 Sep-Oct;2 (5) :527-41.