Nordihydroguaiaretic acid

Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC50=8 μM) and tyrosine kinase inhibitor.

Product Specifications

CAS Number

[500-38-9]

Product Name Alternative

NDGA

UNSPSC

12352005

Hazard Statement

H302

Target

Autophagy; Ferroptosis; Lipoxygenase

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nordihydroguaiaretic-acid.html

Purity

99.93

Solubility

DMSO : 233.33 mg/mL (ultrasonic)

Smiles

CC(CC1=CC=C(O)C(O)=C1)C(C)CC2=CC=C(O)C(O)=C2

Molecular Formula

C18H22O4

Molecular Weight

302.36

Precautions

H302

References & Citations

[1]West M, et al. The arachidonic acid 5-lipoxygenase inhibitor Nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice. J Neurochem. 2004 Oct;91 (1) :133-43.|[2]Lu F, et al. Virtual Screening for Potential Allosteric Inhibitors of Cyclin-Dependent Kinase 2 from Traditional Chinese Medicine. Molecules. 2016 Sep 21;21 (9) . pii: E1259.|[3]Zhang H, et al. Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARα-dependent and -independent pathways. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 1;304 (1) :G72-86.