Nordihydroguaiaretic acid
Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC50=8 μM) and tyrosine kinase inhibitor.
Product Specifications
CAS Number
500-38-9
Product Name Alternative
NDGA
UNSPSC
12352005
Hazard Statement
H302
Target
Autophagy; Ferroptosis; Lipoxygenase
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nordihydroguaiaretic-acid.html
Purity
99.93
Solubility
DMSO : 233.33 mg/mL (ultrasonic)
Smiles
CC(CC1=CC=C(O)C(O)=C1)C(C)CC2=CC=C(O)C(O)=C2
Molecular Formula
C18H22O4
Molecular Weight
302.36
Precautions
H302
References & Citations
[1]West M, et al. The arachidonic acid 5-lipoxygenase inhibitor Nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice. J Neurochem. 2004 Oct;91 (1) :133-43.|[2]Lu F, et al. Virtual Screening for Potential Allosteric Inhibitors of Cyclin-Dependent Kinase 2 from Traditional Chinese Medicine. Molecules. 2016 Sep 21;21 (9) . pii: E1259.|[3]Zhang H, et al. Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARα-dependent and -independent pathways. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 1;304 (1) :G72-86.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Natural Products
Clinical Information
Phase 4
Isoform
5-LOX
Available Sizes
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