α-Synuclein inhibitor 11

α-Synuclein inhibitor 11 (compound 1) is a selective α-synuclein (α-syn) oligomer formation inhibitor. α-Synuclein inhibitor 11 does not inhibits tau 4R (isoforms 0N4R, 2N4R) or p-tau (isoform 1N4R) . α-Synuclein inhibitor 11 can be used for Parkinson's disease (PD) research[1].

Product Specifications

UNSPSC

12352005

Target

α-synuclein

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/α-synuclein-inhibitor-11.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=C(NC(NC2=CC=CC3=C2C=CN3)=O)C=C1)NC4=C(C=CN5)C5=CC=C4

Molecular Formula

C24H20N6O2

Molecular Weight

424.45

References & Citations

[1]Susantha K Ganegamage, et al. 1,4-Diurea- and 1,4-Dithiourea-Substituted Aromatic Derivatives Selectively Inhibit α-Synuclein Oligomer Formation In Vitro. ACS Omega. 2023 Dec 19;9 (1) :1216-1229.