α-Synuclein inhibitor 11
α-Synuclein inhibitor 11 (compound 1) is a selective α-synuclein (α-syn) oligomer formation inhibitor. α-Synuclein inhibitor 11 does not inhibits tau 4R (isoforms 0N4R, 2N4R) or p-tau (isoform 1N4R) . α-Synuclein inhibitor 11 can be used for Parkinson's disease (PD) research[1].
Product Specifications
UNSPSC
12352005
Target
α-synuclein
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/α-synuclein-inhibitor-11.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(NC(NC2=CC=CC3=C2C=CN3)=O)C=C1)NC4=C(C=CN5)C5=CC=C4
Molecular Formula
C24H20N6O2
Molecular Weight
424.45
References & Citations
[1]Susantha K Ganegamage, et al. 1,4-Diurea- and 1,4-Dithiourea-Substituted Aromatic Derivatives Selectively Inhibit α-Synuclein Oligomer Formation In Vitro. ACS Omega. 2023 Dec 19;9 (1) :1216-1229.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α-synuclein Aggregation
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