NVP-AEW541 (dihydrochloride)
Product Specifications
UNSPSC Description
NVP-AEW541 dihydrochloride (AEW541 dihydrochloride) is an orally active inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with an IC50 value of 0.15 μM. NVP-AEW541 dihydrochloride also inhibits InsR, IC50 with a value of 0.14 μM. NVP-AEW541 dihydrochloride has antitumor activity[1].
Target Antigen
Autophagy; IGF-1R; Insulin Receptor
Type
Reference compound
Related Pathways
Autophagy;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nvp-aew541-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
[H]Cl.[H]Cl.NC1=C2C(N([C@@H]3C[C@@H](C3)CN4CCC4)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1
Molecular Weight
512.47
References & Citations
[1]García-Echeverría C, et al. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell. 2004 Mar;5(3):231-9.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-50866B/NVP-AEW541-dihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-50866B/
Clinical Information
No Development Reported
CAS Number
2320261-63-8
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