NVP-AEW541 (dihydrochloride)

NVP-AEW541 dihydrochloride (AEW541 dihydrochloride) is an orally active inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with an IC50 value of 0.15 μM. NVP-AEW541 dihydrochloride also inhibits InsR, IC50 with a value of 0.14 μM. NVP-AEW541 dihydrochloride has antitumor activity[1].

Product Specifications

CAS Number

[2320261-63-8]

Product Name Alternative

AEW541 (dihydrochloride)

UNSPSC

12352005

Target

Autophagy; IGF-1R; Insulin Receptor

Type

Reference compound

Related Pathways

Autophagy; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nvp-aew541-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

[H]Cl.[H]Cl.NC1=C2C(N([C@@H]3C[C@@H](C3)CN4CCC4)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1

Molecular Formula

C27H31Cl2N5O

Molecular Weight

512.47

References & Citations

[1]García-Echeverría C, et al. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell. 2004 Mar;5 (3) :231-9.