What is the catalog number for Curcumin?

The catalog number for Curcumin is HY-N0005.

What sizes are available for Curcumin?

Curcumin is available in the following size(s): 100 mg, 10 mM - 1 mL, 500 mg, 1 g, 5 g.

How many pack sizes does Curcumin come in?

Curcumin is available in 5 different pack sizes.

Is Curcumin in stock?

Curcumin is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Curcumin?

Curcumin is manufactured by QuantiMol.

What is the estimated delivery time for Curcumin?

Estimated delivery time for Curcumin is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Curcumin?

The safety data sheet for Curcumin is available here: http://file.medchemexpress.com/batch_PDF/HY-N0005/Curcumin-SDS-MedChemExpress.pdf.

Curcumin

Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

Product Specifications

CAS Number

458-37-7

Product Name Alternative

Diferuloylmethane; Natural Yellow 3; Turmeric yellow

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Epigenetic Reader Domain; Ferroptosis; Histone Acetyltransferase; Influenza Virus; Keap1-Nrf2; Mitophagy

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; Epigenetics; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Curcumin.html

Purity

98.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CC(/C=C/C1=CC=C(O)C(OC)=C1)=O)/C=C/C2=CC=C(O)C(OC)=C2

Molecular Formula

C21H20O6

Molecular Weight

368.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Gao S, et al. Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion. Food Chem Toxicol. 2013 Jul 18. pii: S0278-6915 (13) 004|[2]Nasiri M, et al. Curcumin and Silibinin Inhibit Telomerase Expression in T47D Human Breast Cancer Cells. Asian Pac J Cancer Prev. 2013;14 (6) :3449-53.|[3]Cao A, et all. Curcumin induces apoptosis in human gastric carcinoma AGS cells and colon carcinoma HT-29 cells through mitochondrial dysfunction and endoplasmic reticulum stress. Apoptosis. 2013 Jul 24. [Epub ahead of print]|[4]Jiang H, et al. Antidepressant-like effects of curcumin in chronic mild stress of rats: Involvement of its anti-inflammatory action. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 20. pii: S0278-5846 (13) 00150-4.|[5]Guo H, et al. Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha, c-Jun and androgen receptor. Pharmazie. 2013 Jun;68 (6) :431-4.|[6]Zhu X, et al. Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model. PLoS One. 2014 Mar 6;9 (3) :e91303.|[7]Balasubramanyam K, et al. Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. J Biol Chem. 2004 Dec 3;279 (49) :51163-71.|[8]Jun Wan Shin, et al. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. Biochem Pharmacol. 2020 Mar;173:113820.|[9]Lucas D. Dias, et al. Curcumin as a photosensitizer: From molecular structure to recent advances in antimicrobial photodynamic therapy. Journal of Photochemistry and Photobiology C: Photochemistry Reviews. Volume 45, December 2020, 100384.|[10]Jiang E, et al. Curcumin Inhibits Oxidative Stress and Apoptosis Induced by H2O2 in Bovine Adipose-Derived Stem Cells (bADSCs) . Animals (Basel) . 2024 Nov 26;14 (23) :3421.