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Fibrillin-1/Asprosin, Human (HEK293, His)

Fibrillin-1 and Asprosin are two proteins generated from the same precursor protein, which is encoded by the Fibrillin 1 gene, through proteolytic cleavage. Fibrillin-1 protein, a member of the fibrillin family, is a crucial structural protein in the formation of microfibrils in the extracellular matrix, maintaining tissue homeostasis and cell adhesion, regulating the availability of growth factors, and inhibiting osteoclastogenesis. In contrast, Asprosin is a hormone primarily secreted by white adipose tissue and is involved in regulating glucose metabolism within the body. Fibrillin-1/Asprosin protein, Human (HEK293, His) is a recombinant protein expressed in HEK293 cells with an N-terminal His tag, comprising a full length of 140 amino acids (S2732-H2871) [1][2][3][4][5][6][7][8][9][10][11].

Product Specifications

Product Name Alternative

Fibrillin-1/Asprosin Protein, Human (HEK293, His), Human, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/asprosin-protein-human-hek293-his.html

Purity

98.0

Smiles

STNETDASNIEDQSETEANVSLASWDVEKTAIFAFNISHVSNKVRILELLPALTTLTNHNRYLIESGNEDGFFKINQKEGISYLHFTKKKPVAGTYSLQISSTPLYKKKELNQLEDKYDKDYLSGELGDNLKMKIQVLLH

Molecular Formula

2200 (Gene_ID) P35555 (S2732-H2871) (Accession)

Molecular Weight

Approximately 25-33 kDa due to the glycosylation.

References & Citations

[1]Jensen SA, et al. New insights into the structure, assembly and biological roles of 10-12 nm connective tissue microfibrils from fibrillin-1 studies. Biochem J. 2016 Apr 1;473 (7) :827-38.|[2]Tiedemann K, et al. Fibrillin-1 directly regulates osteoclast formation and function by a dual mechanism. J Cell Sci. 2013 Sep 15;126 (Pt 18) :4187-94.|[3]Bax DV, et al. Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins. J Biol Chem. 2003 Sep 5;278 (36) :34605-16.|[4]Jovanovic J, et al. alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity. J Biol Chem. 2007 Mar 2;282 (9) :6743-51.|[5]Tiedemann K, et al. Interactions of fibrillin-1 with heparin/heparan sulfate, implications for microfibrillar assembly. J Biol Chem. 2001 Sep 21;276 (38) :36035-42.|[6]Romere C, et al. Asprosin, a Fasting-Induced Glucogenic Protein Hormone. Cell. 2016 Apr 21;165 (3) :566-79.|[7]Lee T, et al. Asprosin impairs insulin secretion in response to glucose and viability through TLR4/JNK-mediated inflammation. Mol Cell Endocrinol. 2019 Apr 15;486:96-104.|[8]Li E, et al. OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin. Cell Metab. 2019 Aug 6;30 (2) :319-328.e8.|[9]Li E, et al. OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin. Cell Metab. 2019 Aug 6;30 (2) :319-328.e8.|[10]Mariko B, et al. Microfibrils and fibrillin-1 induce integrin-mediated signaling, proliferation and migration in human endothelial cells. Am J Physiol Cell Physiol. 2010 Nov;299 (5) :C977-87.|[11]Onat E, et al. The protective effects of humanin in rats with experimental myocardial infarction: The role of asprosin and spexin. Heliyon. 2023 Jul 26;9 (8) :e18739.

Shipping Conditions

Room temperature in continental US; may vary elsewhere.

Storage Conditions

Stored at -20°C for 2 years

Scientific Category

Recombinant Proteins

Available Sizes

Frequently Asked Questions

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