Linopirdine

Linopirdine (DuP 996) is an orally active, selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor with an IC50 of 2.4 μM. Linopirdine is a TRPV1 agonist. Linopirdine, a putative cognition enhancing agent, increases acetylcholine release in rat brain tissue[1][2][3].

Product Specifications

CAS Number

[105431-72-9]

Product Name Alternative

DuP 996

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel; TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/linopirdine.html

Purity

99.90

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1N(C2=CC=CC=C2)C3=C(C=CC=C3)C1(CC4=CC=NC=C4)CC5=CC=NC=C5

Molecular Formula

C26H21N3O

Molecular Weight

391.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Schnee ME, et al. Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons. J Pharmacol Exp Ther. 1998 Aug;286 (2) :709-17.|[2]Nassoiy SP, et al. Kv7 voltage-activated potassium channel inhibitors reduce fluid resuscitation requirements afterhemorrhagic shock in rats. J Biomed Sci. 2017 Jan 17;24 (1) :8.|[3]Neacsu C, et al. The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1. J Pharmacol Sci. 2010;114 (3) :332-40.