STAT3-IN-20

STAT3-IN-20 (Compound 40) is a selective STAT3 inhibitor (IC50: 0.65 μM) . STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells (IC50: 2.97 μM and 3.26 μM respectively) . STAT3-IN-20 induces cell cycle arrest and apoptosis[1].

Product Specifications

CAS Number

[2768427-54-7]

UNSPSC

12352005

Target

STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/stat3-in-20.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

FC1=CC=C(C2=NC3=CC(NC4=NN=C(S4)C5=CC=C(C=C5)C(F)(F)F)=C(C=C3N2C6CC6)N7CCN(CC7)C)C=C1

Molecular Formula

C30H27F4N7S

Molecular Weight

593.64

References & Citations

[1]Wang R, et al. Discovery, Optimization, and Evaluation of Novel N- (Benzimidazol-5-yl) -1,3,4-thiadiazol-2-amine Analogues as Potent STAT3 Inhibitors for Cancer Treatment. J Med Chem. 2023 Aug 18.