MMP-9/10-IN-1
Product Specifications
UNSPSC Description
MMP-9/10-IN-1 (Compound 6b) is a potent dual MMP-9/10 Inhibotor with IC50s of 0.076 and 0.139 μM against NSCLC and A549 cells, respectively. MMP-9/10-IN-1 has anti-invasive and anti-angiogenic activities when in combination with Sorafenib (HY-10201) [1].
Target Antigen
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mmp-9-10-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(NC(N=C(O)N2)=NC2=O)C=C1)NC3=CC=C(Cl)C=C3
Molecular Weight
357.75
References & Citations
[1]Khalil HH, et al. Chemosensitization of non-small cell lung cancer to sorafenib via non-hydroxamate s-triazinedione-based MMP-9/10 inhibitors. Bioorg Chem. 2024 Mar;144:107155.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161284/MMP-9-10-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161284/
Clinical Information
No Development Reported
Curated Selection
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