Mepazine
Mepazine (Pecazine) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine affects viability of ABC-DLBCL cells by enhancing apoptosis[1].
Product Specifications
CAS Number
60-89-9
Product Name Alternative
Pecazine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; MALT1
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mepazine.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1CC(CCC1)CN2C3=C(SC4=CC=CC=C24)C=CC=C3
Molecular Formula
C19H22N2S
Molecular Weight
310.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Nagel D, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell. 2012 Dec 11;22 (6) :825-37.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MR207628L4V 200 µL
Sec61a1 (NM_016906) Mouse Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details