Mepazine
Mepazine (Pecazine) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine affects viability of ABC-DLBCL cells by enhancing apoptosis[1].
Product Specifications
CAS Number
[60-89-9]
Product Name Alternative
Pecazine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; MALT1
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mepazine.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1CC(CCC1)CN2C3=C(SC4=CC=CC=C24)C=CC=C3
Molecular Formula
C19H22N2S
Molecular Weight
310.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Nagel D, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell. 2012 Dec 11;22 (6) :825-37.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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