Mepazine

Mepazine (Pecazine) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine affects viability of ABC-DLBCL cells by enhancing apoptosis[1].

Product Specifications

CAS Number

[60-89-9]

Product Name Alternative

Pecazine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; MALT1

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mepazine.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN1CC(CCC1)CN2C3=C(SC4=CC=CC=C24)C=CC=C3

Molecular Formula

C19H22N2S

Molecular Weight

310.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Nagel D, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell. 2012 Dec 11;22 (6) :825-37.