SHP2-IN-30

SHP2-IN-30 (compound 14i) is an allosteric SHP2 inhibitor with an IC50 of 104 nM. SHP2-IN-30 shows low inhibitory effect on SHP2-PTP. SHP2-IN-30 induces cell apoptosis and arrests the cell cycle at the G0/G1 phase[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; SHP2

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/shp2-in-30.html

Smiles

ClC1=CC=CC(SC(C=C2)=CN3C2=NC(N4CCC(C)(CN)CC4)=CC3=O)=C1Cl

Molecular Formula

C21H22Cl2N4OS

Molecular Weight

449.40

References & Citations

[1]Le Zhang, et al. Design, synthesis, and biological evaluation of Pyrido[1,2-a]pyrimidin-4-one derivatives as novel allosteric SHP2 inhibitors. Bioorg Chem. 2024 Jul 17:151:107661.