SHP2-IN-30
SHP2-IN-30 (compound 14i) is an allosteric SHP2 inhibitor with an IC50 of 104 nM. SHP2-IN-30 shows low inhibitory effect on SHP2-PTP. SHP2-IN-30 induces cell apoptosis and arrests the cell cycle at the G0/G1 phase[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; SHP2
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/shp2-in-30.html
Smiles
ClC1=CC=CC(SC(C=C2)=CN3C2=NC(N4CCC(C)(CN)CC4)=CC3=O)=C1Cl
Molecular Formula
C21H22Cl2N4OS
Molecular Weight
449.40
References & Citations
[1]Le Zhang, et al. Design, synthesis, and biological evaluation of Pyrido[1,2-a]pyrimidin-4-one derivatives as novel allosteric SHP2 inhibitors. Bioorg Chem. 2024 Jul 17:151:107661.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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