Tenovin-6
Tenovin-6, an analog of Tenovin-1 , is an activator of p53 transcriptional activity. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC50s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 also inhibits dihydroorotate dehydrogenase (DHODH)[2].
Product Specifications
CAS Number
1011557-82-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Dihydroorotate Dehydrogenase; MDM-2/p53; Sirtuin
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Tenovin-6.html
Purity
98.00
Solubility
DMSO : ≥ 31 mg/mL
Smiles
O=C(NC(NC1=CC=C(NC(CCCCN(C)C)=O)C=C1)=S)C2=CC=C(C(C)(C)C)C=C2
Molecular Formula
C25H34N4O2S
Molecular Weight
454.63
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT1; SIRT2; SIRT3
Available Sizes
Frequently Asked Questions
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