Androgen receptor-IN-6

Androgen receptor-IN-6 (compound 16) is an orally available androgen receptor (Androgen Receptor) potent inhibitor (IC50=0.12 μM in vitro), targeting the disordered N-terminal domain (NTD) . Androgen receptor-IN-6 has good Caco2 cell membrane permeability and has an oral activity (F/%) of 16% in male CD-1 mice[1].

Product Specifications

CAS Number

[3016437-05-8]

UNSPSC

12352005

Target

Androgen Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/androgen-receptor-in-6.html

Purity

98.26

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN1C2=CC=C(C3=CC(C(N)=O)=CC=C3SC)C=C2C=N1

Molecular Formula

C16H15N3OS

Molecular Weight

297.37

References & Citations

[1]Henry M C et al. Synthesis and evaluation of small molecule inhibitors of the androgen receptor N-terminal domain[J]. ACS Medicinal Chemistry Letters, 2023.