1,2-Dioleoyl-sn-glycero-3-phosphocholine

1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC) is a phospholipid and is commonly used alone, or with other components, in the generation of micelles, liposomes, and other types of artificial membranes.

Product Specifications

CAS Number

[4235-95-4]

Product Name Alternative

DOPC

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H331, H336, H351, H361, H372, H412

Target

Endogenous Metabolite; Liposome

Type

Oligonucleotides

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/1-2-dioleoyl-sn-glycero-3-phosphocholine.html

Purity

98.11

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)

Smiles

CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O

Molecular Formula

C44H84NO8P

Molecular Weight

786.11

Precautions

H302, H315, H319, H331, H336, H351, H361, H372, H412

References & Citations

[1]Sercombe L, et al. Advances and Challenges of Liposome Assisted Drug Delivery. Front Pharmacol. 2015 Dec 1;6:286.|[2]Zelphati O, et al. Mechanism of oligonucleotide release from cationic liposomes. Proc Natl Acad Sci U S A. 1996 Oct 15;93 (21) :11493-8.|[3]Bayburt T H, et al. Self-assembly of discoidal phospholipid bilayer nanoparticles with membrane scaffold proteins[J]. Nano letters, 2002, 2 (8) : 853-856.|[4]Montal M, et al. Formation of bimolecular membranes from lipid monolayers and a study of their electrical properties. Proc Natl Acad Sci U S A. 1972 Dec;69 (12) :3561-6.|[5]Lentz BR. Use of fluorescent probes to monitor molecular order and motions within liposome bilayers. Chem Phys Lipids. 1993 Sep;64 (1-3) :99-116.|[6]Henzler Wildman KA, et al. Mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37. Biochemistry. 2003 Jun 3;42 (21) :6545-58.|[7]Albanese A, et al. The effect of nanoparticle size, shape, and surface chemistry on biological systems. Annu Rev Biomed Eng. 2012;14:1-16.