Ambrisentan
Ambrisentan is a selective ET type A receptor (ETAR) antagonist.
Product Specifications
CAS Number
177036-94-1
Product Name Alternative
BSF 208075; LU 208075
UNSPSC
12352005
Hazard Statement
H360
Target
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Ambrisentan.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 7.14 mg/mL (ultrasonic)
Smiles
O=C([C@H](C(OC)(C1=CC=CC=C1)C2=CC=CC=C2)OC3=NC(C)=CC(C)=N3)O
Molecular Formula
C22H22N2O4
Molecular Weight
378.42
Precautions
H360
References & Citations
[1]Okamoto T, et al. Antifibrotic effects of Ambrisentan, an endothelin-A receptor antagonist, in a non-alcoholic steatohepatitis mouse model. World J Hepatol. 2016 Aug 8;8 (22) :933-41.|[2]Lisk C, et al. Nrf2 activation: a potential strategy for the prevention of acute mountain sickness. Free Radic Biol Med. 2013 Oct;63:264-73.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
ETA
Available Sizes
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