(R) -Nolpitantium
(R) -Nolpitantium is the R-enantiomer of Nolpitantium. Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin NK1 receptor antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation[1].
Product Specifications
CAS Number
154728-59-3
Product Name Alternative
SR140603
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/r-nolpitantium.html
Smiles
O=C(N1C[C@](CC[N+]2(CC3)CCC3(C4=CC=CC=C4)CC2)(C5=CC=C(Cl)C(Cl)=C5)CCC1)CC6=CC=CC(OC(C)C)=C6.[Cl-]
Molecular Formula
C37H45Cl3N2O2
Molecular Weight
656.12
References & Citations
[1]Oury-Donat F, et al. SR 140333, a novel, selective, and potent nonpeptide antagonist of the NK1 tachykinin receptor: characterization on the U373MG cell line. J Neurochem. 1994 Apr;62 (4) :1399-407.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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