(R) -MPH-220

(R) -MPH-220 is the R isomer of MPH-220 (HY-148516) . MPH-220 is a selective and orally active inhibitor of skeletal muscle myosin-2. MPH-220 enables muscle relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness[1].

Product Specifications

UNSPSC

12352005

Target

Myosin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/r-mph-220.html

Purity

99.09

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O[C@]12C(N(C3=CC=C(N4CCOCC4)C=C3)CC2)=NC5=C(C=C(S5)C)C1=O

Molecular Formula

C20H21N3O3S

Molecular Weight

383.46

References & Citations

[1]Gyimesi M, et al. Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness. Cell. 2020 Oct 15;183 (2) :335-346.e13.