N2-Methylguanosine

N2-Methylguanosine is a commonly modified nucleoside in rRNA and tRNA, with specific distributions in both E. coli rRNA and eukaryotic tRNA. N2-Methylguanosine can be found in urine. N2-Methylguanosine affects the structure and stability of RNA[1][2][3].

Product Specifications

CAS Number

[2140-77-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Nucleoside Antimetabolite/Analog

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/N2-Methylguanosine.html

Purity

98.07

Solubility

DMSO : 7.69 mg/mL (ultrasonic)

Smiles

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2N=C(NC)NC3=O)O1

Molecular Formula

C11H15N5O5

Molecular Weight

297.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Ginell SL, et al. Conformation of N2-methylguanosine, a modified nucleoside of tRNA. Biochem Biophys Res Commun. 1978 Oct 30;84 (4) :886-94.|[2]Chheda GB, et al. Nucleosides in human urine. I. Isolation and identification of N2-dimethylguanosine, 1-methylinosine, and N2-methylguanosine from normal human urine. J Pharm Sci. 1969 Jan;58 (1) :75-8.|[3]Pallan PS, et al. Effects of N2, N2-dimethylguanosine on RNA structure and stability: crystal structure of an RNA duplex with tandem m2 2G:A pairs. RNA. 2008 Oct;14 (10) :2125-35. doi: 10.1261/rna.1078508IF: 4.2 Q2 . Epub 2008 Sep 4. Erratum in: RNA. 2008 Nov;14 (11) :2452.