Blarcamesine (hydrochloride)

Blarcamesine hydrochloride (Anavex 2-73) is a Sigma-1 Receptor agonist with an IC50 of 860 nM.

Product Specifications

CAS Number

[195615-84-0]

Product Name Alternative

Anavex 2-73

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Anavex_2-73.html

Purity

99.87

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

CN(C)CC1CCOC1(C2=CC=CC=C2)C3=CC=CC=C3.[H]Cl

Molecular Formula

C19H24ClNO

Molecular Weight

317.85

Precautions

H315, H319, H335

References & Citations

[1]Villard V, et al. Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma 1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative. J Psychopharmacol. 2011 Aug;25 (8) :1101-17.|[2]Valentine Lahmy, et al. Blockade of Tau Hyperphosphorylation and Aβ1-42 Generation by the Aminotetrahydrofuran Derivative ANAVEX2-73, a Mixed Muscarinic andσ1 Receptor Agonist, in a Nontransgenic Mouse Model of Alzheimer's Disease. Neuropsychopharmacology. 2013 Aug; 38 (9) : 1706-1723.