Blarcamesine (hydrochloride)
Product Specifications
UNSPSC Description
Blarcamesine hydrochloride (Anavex 2-73) is a Sigma-1 Receptor agonist with an IC50 of 860 nM.
Target Antigen
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Anavex_2-73.html
Purity
99.87
Solubility
DMSO : 25 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Smiles
CN(C)CC1CCOC1(C2=CC=CC=C2)C3=CC=CC=C3.[H]Cl
Molecular Weight
317.85
References & Citations
[1]Villard V, et al. Anti-amnesic and neuroprotective potentials of the mixed muscarinic receptor/sigma 1 (σ1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative. J Psychopharmacol. 2011 Aug;25(8):1101-17.|[2]Valentine Lahmy, et al. Blockade of Tau Hyperphosphorylation and Aβ1-42 Generation by the Aminotetrahydrofuran Derivative ANAVEX2-73, a Mixed Muscarinic andσ1 Receptor Agonist, in a Nontransgenic Mouse Model of Alzheimer's Disease. Neuropsychopharmacology. 2013 Aug; 38(9): 1706-1723.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101864/Blarcamesine-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101864/Blarcamesine-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
195615-84-0
Available Sizes
Curated Selection
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