8-Br-ADPR
8-Br-ADPR (8-Bromoadenosine-5'-O-diphosphoribose), an analogue of Adenosine 5′-diphosphoribose , is a TRPM2 modulator. 8-Br-ADPR is a human TRPM2 (hsTRPM2) inhibitor and a Nematostella vectensis (nvTRPM2) partial agonist (EC50 of 31.9 µM). 8-Br-ADPR regulates calcium release from the endoplasmic reticulum and sarcoplasmic reticulum[1].
Product Specifications
CAS Number
59259-77-7
Product Name Alternative
8-Bromoadenosine-5'-O-diphosphoribose
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/8-br-adpr.html
Smiles
O[C@H]1[C@@H](O)[C@H](N2C(Br)=NC3=C2N=CN=C3N)O[C@@H]1COP(OP(OC[C@H]4OC(O)[C@H](O)[C@@H]4O)(O)=O)(O)=O
Molecular Formula
C15H22BrN5O14P2
Molecular Weight
638.21
References & Citations
[1]Tóth B, et al. Selective profiling of N- and C-terminal nucleotide-binding sites in a TRPM2 channel. J Gen Physiol. 2020 May 4;152 (5) :e201912533.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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