Ningetinib Tosylate
Ningetinib Tosylate is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC50s of 6.7, 1.9 and c-Met, VEGFR2 and Axl, respectively.
Product Specifications
CAS Number
[1394820-77-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
C-Met/HGFR; TAM Receptor; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Ningetinib_Tosylate.html
Purity
99.59
Solubility
DMSO : 33.33 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
CC1=CC=C(S(=O)(O)=O)C=C1.CC2=C(C(NC3=CC(F)=C(OC4=CC=NC5=C4C=CC(OCC(C)(O)C)=C5)C=C3)=O)C(N(C6=CC=CC=C6)N2C)=O
Molecular Formula
C38H37FN4O8S
Molecular Weight
728.79
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Axl; VEGFR2/KDR/Flk-1
Available Sizes
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