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Cathepsin D and E FRET Substrate (acetate)

Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D[1].

Product Specifications

UNSPSC

12352209

Target

Cathepsin

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cathepsin-d-and-e-fret-substrate-acetate.html

Purity

99.78

Solubility

H2O : 10 mg/mL (ultrasonic)

Smiles

O=C(N1[C@@H](CCC1)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCNC2=C(C=C(C=C2)[N+]([O-])=O)[N+]([O-])=O)C(N[C@@H](C(N)=O)CCCNC(N)=N)=O)=O)=O)=O)CC3=CC=CC=C3)=O)CC4=CC=CC=C4)=O)=O)=O)[C@H](CCCCN)NC(CNC(CC(C5=CC=C(OC)C=C5O6)=CC6=O)=O)=O.CC(O)=O

Molecular Formula

C87H126N22O21

Molecular Weight

1816.15

References & Citations

[1]Y Yasuda, et al. Characterization of new fluorogenic substrates for the rapid and sensitive assay of cathepsin E and cathepsin D. J Biochem

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Isoform

Cathepsin D; Cathepsin E

Available Sizes

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