KLD-12

KLD-12 is a 12-residue self-assembling peptide that is used in tissue-engineering. KLD-12 combined with SDF-1 self-assembled polypeptide enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs) . KLD-12 hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair[1][2][3].

Product Specifications

CAS Number

[800379-47-9]

UNSPSC

12352209

Target

Others

Type

Peptides

Related Pathways

Others

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/kld-12.html

Purity

99.69

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

CC(C)C[C@@H](C(N)=O)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C68H122N16O19

Molecular Weight

1467.79

References & Citations

[1]Cao M, et al., Self-Assembled KLD-12/SDF-1 Polypeptide Promotes Differentiation and Migration of BMSCs via the Wnt/β-catenin Signaling Pathways. Protein Pept Lett. 2022;29 (10) :851-858. |[2]Tripathi JK, et al., Variants of self-assembling peptide, KLD-12 that show both rapid fracture healing and antimicrobial properties. Biomaterials. 2015 Jul;56:92-103. |[3]Kisiday J, Jet al., Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc Natl Acad Sci U S A. 2002 Jul 23;99 (15) :9996-10001.