3-Hydroxyphenylacetic acid

3-Hydroxyphenylacetic acid is an orally active flavonoid metabolite produced by intestinal flora, with blood pressure-lowering activity. 3-Hydroxyphenylacetic acid can also inhibit ferroptosis by upregulating the expression of GPX4, thereby improving spermatogenic dysfunction in aged mice. In addition, abnormal levels of 3-Hydroxyphenylacetic acid are closely related to certain diseases, such as autism spectrum disorders[1][2][3][4].

Product Specifications

CAS Number

[621-37-4]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Aldehyde Dehydrogenase (ALDH) ; Apoptosis; Endogenous Metabolite; Ferroptosis; Glutathione Peroxidase; Keap1-Nrf2; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/3-hydroxyphenylacetic-acid.html

Purity

99.03

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

Smiles

OC1=CC=CC(CC(O)=O)=C1

Molecular Formula

C8H8O3

Molecular Weight

152.15

Precautions

H315, H319, H335

References & Citations

[1]Dias P, et al. 3-Hydroxyphenylacetic Acid: A Blood Pressure-Reducing Flavonoid Metabolite. Nutrients. 2022 Jan 13;14 (2) :328.|[2]Jin Z, et al. The gut metabolite 3-hydroxyphenylacetic acid rejuvenates spermatogenic dysfunction in aged mice through GPX4-mediated ferroptosis. Microbiome. 2023 Sep 27;11 (1) :212.|[3]Liu Y, et al. A Major Intestinal Catabolite of Quercetin Glycosides, 3-Hydroxyphenylacetic Acid, Protects the Hepatocytes from the Acetaldehyde-Induced Cytotoxicity through the Enhancement of the Total Aldehyde Dehydrogenase Activity. Int J Mol Sci. 2022 Feb 3;23 (3) :1762.|[4]Xiong X, et al. Urinary 3- (3-Hydroxyphenyl) -3-hydroxypropionic Acid, 3-Hydroxyphenylacetic Acid, and 3-Hydroxyhippuric Acid Are Elevated in Children with Autism Spectrum Disorders. Biomed Res Int. 2016;2016:9485412.