THAM (hydrochloride)

THAM hydrochloride (Tris HCl) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. THAM hydrochloride is an effective amine compound for pH control in the physiological range[1][2].

Product Specifications

CAS Number

[1185-53-1]

Product Name Alternative

Tris HCl; Tris (hydroxymethyl) aminomethane (hydrochloride)

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Others

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/tham-hydrochloride.html

Purity

99.90

Solubility

DMSO : 200 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

OCC(CO)(N)CO.[H]Cl

Molecular Formula

C4H12ClNO3

Molecular Weight

157.60

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Nahas GG, et al. Guidelines for the treatment of acidaemia with THAM. Drugs. 1998 Feb;55 (2) :191-224.|[2]Höstman S, et al. THAM reduces CO2-associated increase in pulmonary vascular resistance - an experimental study in lung-injured piglets. Crit Care. 2015 Sep 17;19 (1) :331.