Eoxin E4

Eoxin E4 (14,15-LTE4) is the metabolite of 14,15-LTC4 and 14,15-LTD4. Eoxin E4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency than LTC4, but approximately 100-fold greater potency than histamine[1][2].

Product Specifications

CAS Number

1000852-57-2

Product Name Alternative

14,15-LTE4; EoxE4

UNSPSC

12352211

Hazard Statement

H225-H301+H311+H331-H370

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/eoxin-e4.html

Smiles

CCCCC[C@@H]([C@@H](/C=C/C=C/C=C\C/C=C\CCCC(O)=O)SC[C@@H](C(O)=O)N)O

Molecular Formula

C23H37NO5S

Molecular Weight

439.61

Precautions

P210-P233-P240-P241-P242-P243-P260-P261-P264-P270-P271-P280-P302+P352-P303+P361+P353-P304+P340-P308+P311-P330-P361+P364-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]Bryant RW, et al. Leukotriene formation by a purified reticulocyte lipoxygenase enzyme. Conversion of arachidonic acid and 15-hydroperoxyeicosatetraenoic acid to 14, 15-leukotriene A4. J Biol Chem. 1985 Mar 25;260 (6) :3548-55. |[2]Luo M, et al. Leukotriene synthesis by epithelial cells. Histol Histopathol. 2003 Apr;18 (2) :587-95.